Sirolimus Rx
Start provider review

FDA-approved drug

Rapamycin has the best longevity data in pharmacology. None of it is human.

Both halves are true and we publish them together. The NIH's replicated mouse program extended lifespan in both sexes at three independent sites, even starting in late life. Humans have an approved transplant drug with a boxed warning, immune trials that mostly tested a different molecule (everolimus, labeled as such in our table), and one completed longevity trial that missed its primary endpoint. Every study row names its species and its compound; every number links to its source.

Start provider reviewBrowse the guides
  • 23studies in the graded evidence table, species labeled on every row
  • 11of those rows are human studies, and 3 of the human rows tested a different rapalog, labeled in the compound column
  • 0completed human trials with a lifespan or disease-outcome primary endpoint. We print the zero instead of hiding it
  • 33fetch-verified sources, every one peer-reviewed or government

Online care, from intake to delivery

Sirolimus care, made simple

Choose your plan, complete a private medical intake, and connect with a licensed provider. If prescribed, treatment ships discreetly to your door.

Sirolimus care catalog product image
Compounded oral treatmentPrepared after approval
Catalog image. Dispensed product and packaging may vary by pharmacy.

Your care plan includes

Everything you need to get started

From$136.80per month
Licensed providerMedical reviewIf prescribedTreatment includedAt no added costDiscreet shippingWhen you need itOrder support
Choose your planChange or cancel future refills anytime
Due today$152.10then monthly

Encrypted checkout • provider review required • shipping included

  1. 01
    Choose your planSelect the supply and refill preference that works for you.
  2. 02
    Complete your intakeShare your health history in our private, secure flow.
  3. 03
    Provider reviewIf appropriate, your prescription is prepared and shipped.

Prescription treatment requires an online medical evaluation. A provider will determine whether treatment is medically appropriate; approval is not guaranteed.

Key facts

  • StatusFDA-approved drug
  • Tmax noteBlood levels in real-world longevity users peaked about 2 days after a weekly dose (observational data)
  • BioavailabilityAbout 14% (oral solution); tablets about 27% higher than solution; the two are not bioequivalent (clinically equivalent at 2 mg)
  • DistributionBlood-to-plasma ratio 36 +/- 18 (sequestered in red cells); Vss/F 12 +/- 8 L/kg; about 92% protein bound
  • MetabolismSubstrate of CYP3A4 and P-glycoprotein; extensive intestinal and hepatic metabolism
  • Steady state noteDerived: with a 62-hour half-life, steady state arrives in roughly 11 to 13 days (4 to 5 half-lives)
  • RouteOral (solution or tablets), once daily per label
  • Drug classmTOR inhibitor immunosuppressantFDA labelsource
  • Longevity statusOff-label; zero completed lifespan-outcome trialsAbsence of evidencesource
  • Half-lifeAbout 62 +/- 16 hoursFDA labelsource
  • Boxed warningImmunosuppression: infection, lymphoma/malignancy riskFDA labelsource
  • MonitoringWhole-blood troughs; label recommends TDM for all patientsFDA labelsource
  • Key interactionCYP3A4/P-gp substrate; grapefruit prohibited by labelFDA labelsource
  • Approved doses2 mg/day (renal, LAM start); 5 mg/day high-riskFDA labelsource
  • Best animal resultITP mice: +14% (F) / +9% (M) at 90th percentile, late-life startAnimalsource
  • Human evidence caveatFamous elderly immune RCTs used everolimus, not sirolimusDerived from cited datasource

Read the full Rapamycin (sirolimus) monograph

Browse by topic

Everything on Sirolimus (rapamycin), organized the way you research it.

Evidence17 articlesSafety12 articlesSourcing11 articlesDosing11 articlesComparisons5 articles

Free Rapamycin (sirolimus) tools

Practical calculators and references, each scoped and sourced.

T-01Rapamycin doses actually studied in humans (mg/kg visualizer)Shows every sirolimus dose specified by the FDA label or administered in the human studies this site cites, by indication, converted between total mg and mg/kg for a user-entered body weight. Mouse doses appear in their native ppm-of-diet units with an explicit no-conversion note. It answers 'what have humans actually been given, and how does folklore dosing compare' without prescribing anything.T-02Sirolimus interaction screener (label CYP3A4/P-gp lists)Screens a user-selected medication or substance list against the sirolimus FDA label's interaction rules. Renders the label's own categories: avoid (strong CYP3A4/P-gp inhibitors and inducers, grapefruit), timing rules (cyclosporine), monitor closely (cannabidiol), and avoid-during-treatment (live vaccines). Education only; it never says a combination is safe.T-03Sirolimus monitoring planner (what the label says to check)Renders the label's monitoring rules as a timeline: whole-blood trough checks and their timing, the LAM target range, the lab panel the warning sections imply (lipids, glucose, urine protein, blood counts), and the half-life arithmetic that sets the tempo. Education only: it schedules nothing and orders nothing.

All guides

56 in-depth, individually cited guides.

Evidence 17 guides

Is sirolimus worth it? A buyer's reality checkMouse lifespan data is strong, human trials don't exist yet, and side effects are real. Here's the honest math on whether sirolimus is worth trying.Updated 2026-07-30Read guide →
Natural alternatives to sirolimus: what the evidence showsNo supplement matches sirolimus's mTOR inhibition in human trials. Here's what the mouse and human data on resveratrol, rapamycin foods, and fasting actually show.Updated 2026-07-30Read guide →
Sirolimus alternatives: what the evidence actually supportsNo human lifespan trial exists for rapamycin or any alternative. Here's what NIA mouse data, acarbose, metformin, and other candidates actually show.Updated 2026-07-30Read guide →
Sirolimus before and after: what actually changes, and whenWhat sirolimus before and after really shows: mouse lifespan data up to 60% and human case reports on skin and biomarkers, with no completed human trial yet.Updated 2026-07-30Read guide →
Sirolimus first month: what to expect week by weekWhat actually happens in month one of off-label sirolimus: mouth ulcers around week 2, lipid shifts by week 6-8, and why no human lifespan data exists yet.Updated 2026-07-30Read guide →
Sirolimus for beginners: the complete starter guideA plain-language guide to sirolimus for longevity: what it does, why mice live longer, what's untested in humans, and the real risks to know first.Updated 2026-07-30Read guide →
Sirolimus pros and cons: what the evidence actually showsSirolimus extends lifespan up to 60% in mice (NIA ITP) but has zero completed human longevity trials. Here's the real risk-benefit breakdown.Updated 2026-07-30Read guide →
Sirolimus rebound effect: what happens when you stop dosingDoes mTOR rebound when you stop sirolimus? Here's what the mouse data, pharmacokinetics, and human trial gap actually say about rebound risk.Updated 2026-07-30Read guide →
Sirolimus results timeline: what changes and whenMouth ulcers by week 2, labs shift by week 4-8. No human lifespan trial exists yet. Here's the honest week-by-week timeline for off-label sirolimus.Updated 2026-07-30Read guide →
Sirolimus reviews: what the human evidence actually showsSirolimus reviews sort real data from hype: strong mouse lifespan results, zero completed human longevity trials, and real risks to weigh.Updated 2026-07-30Read guide →
Is Sirolimus FDA approved? The honest answerSirolimus is FDA approved as an immunosuppressant, not for longevity. Here's what's approved, what's off-label, and what the human data actually shows.Updated 2026-07-27Read guide →
Sirolimus animal studies vs human evidence: what we knowMice on rapamycin live 9-14% longer (NIA ITP data). Zero completed human lifespan trials exist. Here's the honest gap between the mouse data and the hype.Updated 2026-07-27Read guide →
Sirolimus clinical trials: what human data actually showsNo completed human lifespan trial exists for sirolimus. Here's what PEARL, mouse ITP data, and transplant safety records actually show, with sources.Updated 2026-07-27Read guide →
Sirolimus human studies: what the trials actually showNo completed human trial has tested rapamycin for lifespan. Here's every real human study on sirolimus and aging, what it found, and what's still missing.Updated 2026-07-27Read guide →
Sirolimus mechanism of action: how mTOR inhibition worksSirolimus blocks mTORC1 to mimic caloric restriction in mice, extending median lifespan 9-14%. No completed human lifespan trial exists. Here's the biology.Updated 2026-07-27Read guide →
Sirolimus rapamycin results: what the research actually showsRapamycin extends mouse lifespan 9-26% per NIA data. Human longevity trials don't exist yet. Here's the real evidence, gaps, and risks explained.Updated 2026-07-27Read guide →
What does Sirolimus actually do in the bodySirolimus (rapamycin) blocks mTOR and extends mouse lifespan up to 26%. No completed human longevity trial exists. Here's the real evidence.Updated 2026-07-27Read guide →

Safety 12 guides

Sirolimus and alcohol: what actually happens if you mix themSirolimus doesn't have a classic disulfiram-type alcohol reaction, but drinking still stacks liver, immune, and mouth-ulcer risks. Here's the real data.Updated 2026-07-30Read guide →
Sirolimus in older adults: what the evidence actually showsMice on rapamycin live 9-14% longer (NIA ITP data). No completed human lifespan trial exists. Here's what's real, what's hoped for, and the risks.Updated 2026-07-30Read guide →
Does sirolimus need to be refrigerated? Storage rulesSirolimus tablets and reconstituted vials have different rules. Here's what USP labeling, FDA data and pharmacist guidance say about heat, cold and light.Updated 2026-07-27Read guide →
Is sirolimus safe? What the human and mouse data showSirolimus is FDA-approved for transplant use at immunosuppressive doses. For longevity, it's off-label with no completed human lifespan trial. Here's the real risk data.Updated 2026-07-27Read guide →
Sirolimus and athlete drug testing: is it banned?Sirolimus isn't on WADA's Prohibited List by name, but its immunosuppressive and metabolic effects raise real questions. Here's what athletes need to know.Updated 2026-07-27Read guide →
Sirolimus and blood work: which labs, and how oftenSirolimus and blood work explained: lipid panel, CBC, glucose, trough levels. What off-label users test, how often, and why the human safety data is thin.Updated 2026-07-27Read guide →
Sirolimus contraindications: who should not take rapamycinSirolimus (rapamycin) is contraindicated in pregnancy, active infection, and certain lung and liver conditions. No human longevity trial exists to weigh against these risks.Updated 2026-07-27Read guide →
Sirolimus drug interactions: the full safety rundownCYP3A4/P-gp interactions, grapefruit, vaccines, and the immunosuppression risk of off-label rapamycin. What actually matters, backed by FDA labeling and NIH data.Updated 2026-07-27Read guide →
Sirolimus in women: what the evidence actually showsNo human lifespan trial has ever tested rapamycin in women. Here's what mouse data, transplant records, and off-label reports actually say about sex differences.Updated 2026-07-27Read guide →
Sirolimus legal status: what's FDA-approved vs. off-labelSirolimus is FDA-approved for transplant rejection, not aging. Longevity dosing is 100% off-label and legal only via prescription. Here's the real regulatory picture.Updated 2026-07-27Read guide →
Sirolimus long term side effects: what the data showsNo human trial has tracked low-dose rapamycin past a few years. Here's what transplant data, mouse studies, and case reports tell us about long-term risk.Updated 2026-07-27Read guide →
Sirolimus side effects: what the data actually showsMouth ulcers, high cholesterol, low white cells: sirolimus's real side effect profile, drawn from transplant data, since no completed human longevity trial exists.Updated 2026-07-27Read guide →

Sourcing 11 guides

Sirolimus compounded vs brand name: what actually differsCompounded sirolimus and brand Rapamune are the same molecule, but strength, price (often $60-150/mo vs $500+), and FDA oversight differ. Here's the real comparison.Updated 2026-07-30Read guide →
Sirolimus cost per month: what it actually runs in 2026Generic sirolimus runs about $30-90/month at retail; compounded low-dose protocols with a telehealth visit run $100-250/month. Here's the real breakdown.Updated 2026-07-30Read guide →
Sirolimus online prescription requirements: what's legalA real US prescription (labs, MD/NP sign-off) is legally required for sirolimus. Here's what compliant telehealth actually requires and where the gray areas are.Updated 2026-07-30Read guide →
Sirolimus price without insurance: what it actually costsGeneric sirolimus runs roughly $20 to $200+ a month uninsured depending on dose, pharmacy, and brand vs generic. Here's the real breakdown.Updated 2026-07-30Read guide →
Sirolimus telehealth options: what you're actually buyingTelehealth sirolimus costs $100-$300+/month, needs a prescriber and labs, and covers a drug never tested for human lifespan extension. Here's the real checklist.Updated 2026-07-30Read guide →
Where to buy sirolimus legally in the US (2026 guide)Sirolimus needs a prescription in every US state; there's no legal OTC or import route. Here's how the prescribing, pharmacy, and telehealth pathways actually work.Updated 2026-07-30Read guide →
How to verify Sirolimus quality before you buyA buyer's checklist for verifying sirolimus (rapamycin) quality: pharmacy licensing, USP standards, third-party testing, and what a legit provider actually shows you.Updated 2026-07-27Read guide →
Sirolimus certificate of analysis explainedWhat a sirolimus certificate of analysis actually verifies, what it can't tell you, and how to read one before you trust a compounded vial.Updated 2026-07-27Read guide →
Sirolimus: compounding pharmacy vs research supplierCompounded sirolimus needs a prescription and USP <795> oversight; 'research' vials skip both. Here's what actually differs, and why it matters for safety.Updated 2026-07-27Read guide →
Sirolimus prescription requirements: what you actually needSirolimus needs a prescription in the US, no exceptions. Here's what that means for longevity dosing, telehealth routes, and why FDA has approved zero anti-aging use.Updated 2026-07-27Read guide →
Sirolimus purity and testing: what buyers should verifyCompounded sirolimus isn't FDA-batch-tested like Rapamune. Here's what USP <795> means, what a COA should show, and what to ask before you buy.Updated 2026-07-27Read guide →

Dosing 11 guides

How long does sirolimus take to workBlood levels build in 5-8 days, but longevity benefits (if any) are unproven in humans. Here's the real timeline for mTOR inhibition, side effects, and labs.Updated 2026-07-27Read guide →
How to reconstitute Sirolimus: a step by step guideSirolimus comes as a lyophilized powder that needs reconstitution before dosing. Here is the exact process, storage rules, and dosing math, step by step.Updated 2026-07-27Read guide →
Sirolimus cost and pricing: what you actually payGeneric sirolimus runs roughly $25 to $100+ a month at retail; compounded off-label vials often cost $150 to $400+. Here's the real pricing breakdown.Updated 2026-07-27Read guide →
Sirolimus cycle length: how long is a dosing cycle?Most off-label rapamycin protocols use once-weekly dosing, not cycles with breaks. Here's what the human PK data and mouse studies actually support.Updated 2026-07-27Read guide →
Sirolimus dosage: what the human and mouse data showSirolimus longevity dosing runs 1-10mg weekly off-label, but no completed human lifespan trial exists. See the mouse data, risks, and dosing logic.Updated 2026-07-27Read guide →
Sirolimus dosage calculator: why none exist and what to use insteadNo validated sirolimus dosage calculator exists for longevity use. Here's what human trial and transplant data actually show, and how doses get set in practice.Updated 2026-07-27Read guide →
Sirolimus half-life: how long it stays in your systemSirolimus has a mean elimination half-life of about 62 hours in adults. Here's what that means for dosing intervals, blood levels, and clearing the drug.Updated 2026-07-27Read guide →
Sirolimus how to inject: a step-by-step protocolHow sirolimus is actually injected off-label for longevity use, needle size, sites, storage, and the human-trial gap that still exists at every step.Updated 2026-07-27Read guide →
Sirolimus injection sites: where and how it's givenSirolimus isn't an injectable in standard use. Here's why, how oral dosing actually works, and what 'injection site' questions usually really mean.Updated 2026-07-27Read guide →
Sirolimus storage and shelf life: the real rulesHow to store sirolimus (rapamycin) correctly, how long reconstituted vials last, and what heat, light, and freezing actually do to potency. Real numbers, real sources.Updated 2026-07-27Read guide →
Sirolimus timeline: what to expect week by weekWhat actually happens on a low-dose rapamycin protocol, week 1 through month 6, based on trial data and pharmacokinetics. No completed longevity trial exists.Updated 2026-07-27Read guide →

Comparisons 5 guides

Sirolimus vs acarbose: comparing the longevity evidenceBoth extend mouse lifespan in the NIA ITP. Only one is FDA-approved for anything. Here's how rapamycin and acarbose actually compare for longevity use.Updated 2026-07-27Read guide →
Sirolimus vs metformin for longevity: what the evidence saysRapamycin extends mouse lifespan up to 26% in NIA-funded trials; metformin's own aging trial (TAME) never got funded. Neither has human longevity data.Updated 2026-07-27Read guide →
Sirolimus vs NAD+: comparing the longevity evidenceSirolimus has decade-long mouse lifespan data from the NIA's ITP; NAD+ boosters mostly have biomarker studies. Neither has a completed human lifespan trial.Updated 2026-07-27Read guide →
Sirolimus vs rapamycin vs everolimus: what's differentSirolimus and rapamycin are the same drug. Everolimus is a cousin. Here's what differs in half-life, dosing, and the human longevity data (none of it complete).Updated 2026-07-27Read guide →
Sirolimus vs senolytics: how the longevity evidence comparesRapamycin has NIA-backed mouse lifespan data; senolytics like dasatinib+quercetin don't. Neither has a completed human lifespan trial. Compare the evidence.Updated 2026-07-27Read guide →

Get the two-column brief: what the mice proved, what humans have not

One email: the ITP results at species grade, the compound-labeled human trial table, the label's monitoring checklist, and the studied-doses table, all cited. Updates only when a label or trial changes something. No dosing advice by email. Unsubscribe anytime.

Free. No spam, unsubscribe anytime. Your address is used for this brief and nothing else.

Start provider review