Sirolimus Rx / Evidence
Evidence
Is Sirolimus Rx FDA approved? The honest answer
Sirolimus is FDA approved as an immunosuppressant, not for longevity. Here's what's approved, what's off-label, and what the human data actually shows.
Sirolimus animal studies vs human evidence: what we know
Mice on rapamycin live 9-14% longer (NIA ITP data). Zero completed human lifespan trials exist. Here's the honest gap between the mouse data and the hype.
Sirolimus clinical trials: what human data actually shows
No completed human lifespan trial exists for sirolimus. Here's what PEARL, mouse ITP data, and transplant safety records actually show, with sources.
Sirolimus human studies: what the trials actually show
No completed human trial has tested rapamycin for lifespan. Here's every real human study on sirolimus and aging, what it found, and what's still missing.
Sirolimus mechanism of action: how mTOR inhibition works
Sirolimus blocks mTORC1 to mimic caloric restriction in mice, extending median lifespan 9-14%. No completed human lifespan trial exists. Here's the biology.
Sirolimus rapamycin results: what the research actually shows
Rapamycin extends mouse lifespan 9-26% per NIA data. Human longevity trials don't exist yet. Here's the real evidence, gaps, and risks explained.
What does Sirolimus Rx actually do in the body
Sirolimus (rapamycin) blocks mTOR and extends mouse lifespan up to 26%. No completed human longevity trial exists. Here's the real evidence.