Sirolimus Rx / Safety
Safety
Does sirolimus need to be refrigerated? Storage rules
Sirolimus tablets and reconstituted vials have different rules. Here's what USP labeling, FDA data and pharmacist guidance say about heat, cold and light.
Is sirolimus safe? What the human and mouse data show
Sirolimus is FDA-approved for transplant use at immunosuppressive doses. For longevity, it's off-label with no completed human lifespan trial. Here's the real risk data.
Sirolimus and athlete drug testing: is it banned?
Sirolimus isn't on WADA's Prohibited List by name, but its immunosuppressive and metabolic effects raise real questions. Here's what athletes need to know.
Sirolimus and blood work: which labs, and how often
Sirolimus and blood work explained: lipid panel, CBC, glucose, trough levels. What off-label users test, how often, and why the human safety data is thin.
Sirolimus contraindications: who should not take rapamycin
Sirolimus (rapamycin) is contraindicated in pregnancy, active infection, and certain lung and liver conditions. No human longevity trial exists to weigh against these risks.
Sirolimus drug interactions: the full safety rundown
CYP3A4/P-gp interactions, grapefruit, vaccines, and the immunosuppression risk of off-label rapamycin. What actually matters, backed by FDA labeling and NIH data.
Sirolimus rx in women: what the evidence actually shows
No human lifespan trial has ever tested rapamycin in women. Here's what mouse data, transplant records, and off-label reports actually say about sex differences.
Sirolimus legal status: what's FDA-approved vs. off-label
Sirolimus is FDA-approved for transplant rejection, not aging. Longevity dosing is 100% off-label and legal only via prescription. Here's the real regulatory picture.
Sirolimus long term side effects: what the data shows
No human trial has tracked low-dose rapamycin past a few years. Here's what transplant data, mouse studies, and case reports tell us about long-term risk.
Sirolimus Rx side effects: what the data actually shows
Mouth ulcers, high cholesterol, low white cells: sirolimus's real side effect profile, drawn from transplant data, since no completed human longevity trial exists.