Sirolimus (rapamycin)
Email me the evidence briefDosing
DosingHow long does sirolimus take to workBlood levels build in 5-8 days, but longevity benefits (if any) are unproven in humans. Here's the real timeline for mTOR inhibition, side effects, and labs.Read guide →DosingHow to reconstitute Sirolimus: a step by step guideSirolimus comes as a lyophilized powder that needs reconstitution before dosing. Here is the exact process, storage rules, and dosing math, step by step.Read guide →DosingSirolimus cost and pricing: what you actually payGeneric sirolimus runs roughly $25 to $100+ a month at retail; compounded off-label vials often cost $150 to $400+. Here's the real pricing breakdown.Read guide →DosingSirolimus cycle length: how long is a dosing cycle?Most off-label rapamycin protocols use once-weekly dosing, not cycles with breaks. Here's what the human PK data and mouse studies actually support.Read guide →DosingSirolimus dosage: what the human and mouse data showSirolimus longevity dosing runs 1-10mg weekly off-label, but no completed human lifespan trial exists. See the mouse data, risks, and dosing logic.Read guide →DosingSirolimus dosage calculator: why none exist and what to use insteadNo validated sirolimus dosage calculator exists for longevity use. Here's what human trial and transplant data actually show, and how doses get set in practice.Read guide →DosingSirolimus half-life: how long it stays in your systemSirolimus has a mean elimination half-life of about 62 hours in adults. Here's what that means for dosing intervals, blood levels, and clearing the drug.Read guide →DosingSirolimus how to inject: a step-by-step protocolHow sirolimus is actually injected off-label for longevity use, needle size, sites, storage, and the human-trial gap that still exists at every step.Read guide →DosingSirolimus injection sites: where and how it's givenSirolimus isn't an injectable in standard use. Here's why, how oral dosing actually works, and what 'injection site' questions usually really mean.Read guide →DosingSirolimus storage and shelf life: the real rulesHow to store sirolimus (rapamycin) correctly, how long reconstituted vials last, and what heat, light, and freezing actually do to potency. Real numbers, real sources.Read guide →DosingSirolimus timeline: what to expect week by weekWhat actually happens on a low-dose rapamycin protocol, week 1 through month 6, based on trial data and pharmacokinetics. No completed longevity trial exists.Read guide →